Santo Spirito is a lively neighbourhood in Florence’s Oltrarno, across the Arno from the historic centre. Around Piazza Santo Spirito, market stalls, cafés and old workshops give the area a lived-in character, even as visitors come for its Renaissance art and evening scene.
The neighbourhood takes its name from the Basilica di Santo Spirito, designed by Filippo Brunelleschi in the 15th century. Its plain façade contrasts with an interior of orderly columns and arches, and the church houses a wooden crucifix attributed to the young Michelangelo. Nearby streets preserve the Oltrarno’s craft traditions, with small botteghe working in fields such as woodworking, leather and restoration.
Come in the morning to browse the market and explore the quieter lanes, then return for aperitivo as the piazza fills with conversation. Santo Spirito is also a useful starting point for visiting the Pitti Palace, Boboli Gardens and Brancacci Chapel. Check the basilica’s opening hours before setting out, as it can close for a midday break and on certain days. The neighbourhood is easily reached on foot from the city centre; if staying near the square, request a room away from the piazza for a quieter night.